# HFB200603 IND Filing

HFB200603 IND filing is anticipated in the second half of 2022.

## Overview of HFB200603
- Proportional dose near or proportional dose in dose with exposure in increase.
- Necropsy at changes macroscopic no observation detectable ADA no clinical with manner temperature, a in suppression.
- TCR 200603 HFB of mediated-HVEM antibody parental reverse to the ability is 3-6 their HFB.

### Functional Characteristics
- Based antibody blocking selected were BTLA-anti blockers benchmark a is Ab Functional.
- CDRs Bmk. Cells diverse with reporter luc- binders NFAT. BTLA BTLA.
- Jurkat potent immune profiling platform - single Drug Intelligent Science (DIS HiFiBiO’s).

## Toxicokinetic Analysis
- Body collected weight, body consumption, food in abnormalities No. 200603 HF of analysis.
- Screening for immunized cell single based- Splenocytes droplet ™ CelliGO to subjected and enriched.
- Protein fusion favorable developability and pharmacokinetic profiles were group was per plasma which after cynomolgus infusion.

## Evaluations
- Experimental design 200603 HFB of obvious (high) mg/kg Scheme 
- NHPs (medium) 200603 mg/kg HFB of mg/kg evaluation 1h of 336 dose toxicological single.
- Points with Exploratory.5 administered.

## Conclusions
- Favorable acute toxicity profile in cynomolgus monkeys in primary tumor culture and pro-inflammatory cytokine production γ 1 in inducing IFN.
- PD-Exhibit single agent effect and combinatorial effect with anti binding blocking activity.
- Potent ligand and digit nanomolar affinity BTLA with single cyno binding specifically to human/mAb BTLA.

## References and Results
- Highlight of HFB200603: 100mg/kg, Male HFB200603, 10mg/kg, Female.
- Diverse CDRs HVEM interaction and selected clinical BTLA antibodies capable of blocking BTLA.
- HFB200603 was characterized for binding affinity, cross-reaction with anti melanoma, NSCLC, and HCC.

### Results Summary
Presenting Qian Zhang, Bingqing Shen, Manan Shah, Mingjie Chen, Sharon Li, Ling Dong, Francisco Adrian, Liang Schweizer, Juying Li.